Agriculture was practiced in Southern Patagonia, however the Northern areas of the region relied on a hunter-gatherer lifestyle.
The hunter gatherer lifestyle was likely preferred due to the abundance of guanaco game.
In the late 15th century, the Native tribes of the Quebrada de Humahuaca were conquered by the Inca Empire, under Topa Inca Yupanqui
Forced to supply metals such as silver, zinc and copper

The Portuguese landed in the region in 1502 by Goncalo Coelho and Amerigo Vespucci
Around 1512 Joao de Lisboa and Estevao discovered Rio de La Plata and the Charrua people. Here they learnt about the Inca Empire
From the mid 1500s, the Spanish started establishing settlements in the region.
The Spanish established the Viceroyalty of the Rio de la Plata in 1776, which consisted of todays Argentina, Uruguay and Paraguay
The British invaded in 1806 and 1807 after winning the battle of Trafalgar but failed each time, The Peninsular War created concern over the Viceroyalty and the people of the Viceroyalty began to consider self government

Buenos Aires declared self government in 1810, starting the Argentine War of Independence from Spain. and was officially declared independent in 1816
Massive European immigration and agriculture through the 1800s and early 1900s
Several military coups and economic crises since then